The Saints squad will again be stretched to the limits as they travel to Liverpool hoping to gain a point or three that could see Premier League safety completely and mathematically secured with four game still left to play.
Those that were predicting that Saints were in freefall and would be relegated were proved wrong and the team travel to the North West on Saturday knowing that by the end of the weekend they could be mathematically safe from relegation.
A win for Saints would see them on 40 points, a total that West Brom currently on 26 points could not reach and Fulham could only match should they win all of their last 4 games.
But a draw or even defeat for Saints could just about push us over the safety line with West Brom facing a tough trip to Arsenal on Sunday and then on Monday evening Fulham taking on Burnley.
But if we get anything at Anfield we will once again have to do it the hard way as it seems the squad will be depleted with injury, ineligibility and perhaps even suspension.
Danny Ings, Oriol Romeu, Ryan Bertrand & Will Smallbone are all likely to be missing through injury, whilst loanee Takumi Minamino is not able to play against his parent club under the Premier League rules.
The club are also still waiting for news as to whether Jannik Vestergaard's first-half red card during Friday night's draw against Leicester will be overturned.
So that is the possibility of six players from the squad being unavailable although Michael Obafemi could well return to the bench after a number of months out.