| Omicron 11:01 - Nov 30 with 28331 views | RonaldStump |
Well, well.well .. the symptoms of the 'new variant' have, so far, only happened in vaccinated people and they have the same complications as severe vaccine reactions.
Didn't see that one coming did we
How convenient... we don't have to blame the vaccines anymore!!
Awake yet? .........surely you are |  |
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| Omicron on 22:39 - Dec 6 with 3643 views | Professor |
| Omicron on 22:26 - Dec 6 by A_Fans_Dad |
Then you don't know as much as you think do you. |
Sorry. I forgot you are the Regius Professor of Medicine.
Having studies modules in both biochemistry (one word) and pharmacology I can assure you they are distinct branches of biological sciences. There is a degree of overlap, but you are so wrong. I can’t see an obvious way ivermectin works against viruses at a dose that is safe. Notably there was a retraction of one proposed mechanism- as basically it was made up.
It’s an odd class of drugs anyway. Sort of sits alone. | | | |
| Omicron on 06:25 - Dec 7 with 3588 views | Professor |
That paper is shockingly awful. Completely no relationship to virology. Put ivermectin on human ovarian cancer cell line and look at pathways with your fancy proteomics kit. Then claim it identities pathways associated with anti-viral activity. No virus involved. Also, one of the reasons ivermectin is of relatively low side effects, is it’s pharmacological mode of action is exclusive to invertebrate nervous system. Biologically it’s complete rubbish. Hence not in a journal associated with infection but one of proteomics methods.
And it’s still pharmacology and perhaps if you knew a little about it you would not post so much rubbish. | | | |
| Omicron on 09:45 - Dec 7 with 3540 views | A_Fans_Dad |
| Omicron on 06:25 - Dec 7 by Professor |
That paper is shockingly awful. Completely no relationship to virology. Put ivermectin on human ovarian cancer cell line and look at pathways with your fancy proteomics kit. Then claim it identities pathways associated with anti-viral activity. No virus involved. Also, one of the reasons ivermectin is of relatively low side effects, is it’s pharmacological mode of action is exclusive to invertebrate nervous system. Biologically it’s complete rubbish. Hence not in a journal associated with infection but one of proteomics methods.
And it’s still pharmacology and perhaps if you knew a little about it you would not post so much rubbish. |
So, you didn't read past table 1 and don't want to understand what they are doing in identifying what Protiens Ivermectin regulated and interleukins in SARSâ€CoVâ€2â€induced cytokine storm, such as TNFB1, IL18, and IL1F10.
OK.
I am sure that you know more about the subject than they do. | | | |
| Omicron on 10:07 - Dec 7 with 3524 views | Professor |
| Omicron on 09:45 - Dec 7 by A_Fans_Dad |
So, you didn't read past table 1 and don't want to understand what they are doing in identifying what Protiens Ivermectin regulated and interleukins in SARSâ€CoVâ€2â€induced cytokine storm, such as TNFB1, IL18, and IL1F10.
OK.
I am sure that you know more about the subject than they do. |
pretty sure I do.
They have just run pathway analysis following their interrogation. It's complete rubbish.
A transformed ovarian (cancerous) cell line with a huge among of drug-it has no physiological relevance, I read the methods first. Absolutely no way that should have been accepted and is completely the reason it's in a proteomics journal.
Now if they had done some analysis in say a SARS CoV2 infection model (Syrian Golden Hamster is the best) to show action (which is what a pharmacological study would involve) then I may consider it. Even infection of a cell line. This is just opportunistic crap with no relevance whatsoever.
Problem is your Bio Chemistry (sic) reading means you don't
1. Understand pharmacology to any meaningful extent
2. Understand the relevance of a proper in vitro or in vivo model.
Now point 2 I know a lot about. 1 enough to get by and understand my knowledge gaps and inexperience in this area.
You clearly can't
You don't understand, that's the problem | | | |
| Omicron on 10:33 - Dec 7 with 3502 views | Boundy |
| Omicron on 10:07 - Dec 7 by Professor |
pretty sure I do.
They have just run pathway analysis following their interrogation. It's complete rubbish.
A transformed ovarian (cancerous) cell line with a huge among of drug-it has no physiological relevance, I read the methods first. Absolutely no way that should have been accepted and is completely the reason it's in a proteomics journal.
Now if they had done some analysis in say a SARS CoV2 infection model (Syrian Golden Hamster is the best) to show action (which is what a pharmacological study would involve) then I may consider it. Even infection of a cell line. This is just opportunistic crap with no relevance whatsoever.
Problem is your Bio Chemistry (sic) reading means you don't
1. Understand pharmacology to any meaningful extent
2. Understand the relevance of a proper in vitro or in vivo model.
Now point 2 I know a lot about. 1 enough to get by and understand my knowledge gaps and inexperience in this area.
You clearly can't
You don't understand, that's the problem |
All I can say is AFD stick to what you know not what you think you know ,from a lecturer in mechanical engineering to the worlds expert on renewable energy and now an expert on bio chemistry all in one easy movement . | |
| "In a free society, the State is the servant of the people—not the master." |
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| Omicron on 11:15 - Dec 7 with 3481 views | Professor |
| Omicron on 10:33 - Dec 7 by Boundy |
All I can say is AFD stick to what you know not what you think you know ,from a lecturer in mechanical engineering to the worlds expert on renewable energy and now an expert on bio chemistry all in one easy movement . |
Important point that. Having a good understanding means knowing where that ends. | | | |
| Omicron on 13:58 - Dec 7 with 3454 views | CountyJim |
Just saying on radio the vaccinated should only get mild cold like symptoms they are more worried about those with low immunity and un vaccinated |  | | |
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| Omicron on 15:04 - Dec 7 with 3440 views | hobo |
| Omicron on 13:58 - Dec 7 by CountyJim |
Just saying on radio the vaccinated should only get mild cold like symptoms they are more worried about those with low immunity and un vaccinated |
Unvaccinated have their immune system so unlikely to bother them. Those with low immunity can have those new covid pills which are supposed to be quite good. Time to remove all restrictions |  | | |
| Omicron on 15:31 - Dec 7 with 3420 views | Scotia |
| Omicron on 15:04 - Dec 7 by hobo |
Unvaccinated have their immune system so unlikely to bother them. Those with low immunity can have those new covid pills which are supposed to be quite good. Time to remove all restrictions |
The new covid pills are about 30% effective and not yet available. | | | |
| Omicron on 15:35 - Dec 7 with 3420 views | Boundy |
| Omicron on 15:04 - Dec 7 by hobo |
Unvaccinated have their immune system so unlikely to bother them. Those with low immunity can have those new covid pills which are supposed to be quite good. Time to remove all restrictions |
Imo not all immune systems act the same especially combined with other medical factors which may exist . | |
| "In a free society, the State is the servant of the people—not the master." |
| |
| Omicron on 15:51 - Dec 7 with 3405 views | majorraglan |
| Omicron on 15:35 - Dec 7 by Boundy |
Imo not all immune systems act the same especially combined with other medical factors which may exist . |
Spot on. Lots of those patients vaccinated in the early phases of the the campaign, the very old, the people in care homes, people with the immune suppression issues (for example previous or existing cancer treatments, rheumatoid arthritis, transplants etc etc etc) will most certainly have significant vulnerabilities, the vaccines will help their immune systems considerably but it doesn’t make them invincible and as the other conditions they are being treated for take their toll they become more prone to infection and some, sadly, will pass away. The hospitals are seeing vaccinated patients in these categories being admitted some are passing away, but the profile of the unvaccinated patients being admitted to hospital is different, they are much younger, including 30’s, 40’s and 50’s - diabetes can be a factor but most are healthy. | | | |
| Omicron on 16:58 - Dec 7 with 3386 views | Professor |
| Omicron on 15:51 - Dec 7 by majorraglan |
Spot on. Lots of those patients vaccinated in the early phases of the the campaign, the very old, the people in care homes, people with the immune suppression issues (for example previous or existing cancer treatments, rheumatoid arthritis, transplants etc etc etc) will most certainly have significant vulnerabilities, the vaccines will help their immune systems considerably but it doesn’t make them invincible and as the other conditions they are being treated for take their toll they become more prone to infection and some, sadly, will pass away. The hospitals are seeing vaccinated patients in these categories being admitted some are passing away, but the profile of the unvaccinated patients being admitted to hospital is different, they are much younger, including 30’s, 40’s and 50’s - diabetes can be a factor but most are healthy. |
Nothing we can do about the decline in immune function with age-immunosenesence. Like the increased incidence of cancer , the decline cellular regulation with age means less efficacy of vaccines. No vaccine makes one invincible, but gives you better weapons to fight. | | | |
| Omicron on 17:04 - Dec 8 with 3296 views | A_Fans_Dad |
Here we have the views of a Professor who studied BioChemistry for a short period decades ago on Proteomics.
"Put ivermectin on human ovarian cancer cell line and look at pathways with your fancy proteomics kit. Then claim it identities pathways associated with anti-viral activity. No virus involved"
And
"Biologically it’s complete rubbish"
and
"They have just run pathway analysis following their interrogation. It's complete rubbish. "
and
"Absolutely no way that should have been accepted and is completely the reason it's in a proteomics journal."
"This is just opportunistic crap with no relevance whatsoever."
Then we have the view of the rest of the world view of Proteomics.
"branch of biotechnology concerned with applying the techniques of molecular biology, biochemistry, and genetics to analyzing the structure, function, and interactions of the proteins produced by the genes of a particular cell, tissue, or organism"
"more inclusive definition combines protein studies with analyses that have a genetic readout such as mRNA analysis, genomics, and the yeast two-hybrid analysis (123). However, the goal of proteomics remains the same, i.e., to obtain a more global and integrated view of biology by studying all the proteins of a cell rather than each one individually."
"Proteomics can provide significant biological information for many biological problems, such as:
which proteins interact with a particular protein of interest (for example, the tumour suppressor protein p53)? (Human example)
which proteins are localised to a subcellular compartment (for example, the mitochondrion)? (Human example)
which proteins are involved in a biological process"
"Proteomics is the analysis of complete complements of proteins and includes not only their identification, but also quantitation, determination of cellular location, how they are modified, how they interact with each other, their activities and, ultimately, the elucidation of protein function. This powerful analysis can, for example, allow differences in the protein levels of samples between diseased and normal tissues to be assessed. Proteins are generally enzymatically digested (with or without pre-fractionation) to produce peptides which are then analysed by state-of-the-art mass spectrometry techniques."
"Accordingly, proteomics seeks to do more than just to identify proteins potentially present in a sample, but also to assess protein abundance, localization, posttranslational modifications, isoforms, and molecular interactions. As a discipline, proteomics has grown at the interface of physical and biochemistry, computer science, and bioinformatics, with an emphasis on high throughput and reduced user bias. Accordingly, technologies used are varied, but almost always utilize coupled techniques (i.e., one- or two-dimensional gel electrophoresis/mass spectrometry (MS) or liquid chromatography/MS). "
As the main problem with COVID revolves around the "Spike Proteins" one would think that it was a good technique to use to learn how to inhibit their actions wouldn't you. | | | |
| Omicron on 20:41 - Dec 8 with 3269 views | max936 |
| Omicron on 15:35 - Dec 7 by Boundy |
Imo not all immune systems act the same especially combined with other medical factors which may exist . |
A relative of one of the Wife's friends is very ill in Hospital, totally refused the vaccine they are probably regretting that decision now.  |  |
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| Omicron on 16:26 - Dec 9 with 3215 views | controversial_jack |
As a new variant becomes dominant, what happens to the older ones? As Omicron becomes the dominant one, what will happen to the Delta variant? | | | |
| Omicron on 16:37 - Dec 9 with 3209 views | onehunglow |
| Omicron on 10:33 - Dec 7 by Boundy |
All I can say is AFD stick to what you know not what you think you know ,from a lecturer in mechanical engineering to the worlds expert on renewable energy and now an expert on bio chemistry all in one easy movement . |
Maybe simply accept one is wrong .
They don’t simply hand out professorships
What is Ron anyway ? AFD too.
They haven’t a cure for COVID though | |
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| Omicron on 16:59 - Dec 9 with 3206 views | Professor |
| Omicron on 16:26 - Dec 9 by controversial_jack |
As a new variant becomes dominant, what happens to the older ones? As Omicron becomes the dominant one, what will happen to the Delta variant? |
Will be out competed and largely disappear.
As alpha did to the Wuhan strain and then delta to alpha | | | |
| Omicron on 17:13 - Dec 9 with 3192 views | controversial_jack |
| Omicron on 16:59 - Dec 9 by Professor |
Will be out competed and largely disappear.
As alpha did to the Wuhan strain and then delta to alpha |
Thank you for the reply, very interesting.Does it mean Variants become weaker or stronger? I know it's the million dollar question, but just curious | | | |
| Omicron on 17:24 - Dec 9 with 3179 views | Professor |
| Omicron on 17:13 - Dec 9 by controversial_jack |
Thank you for the reply, very interesting.Does it mean Variants become weaker or stronger? I know it's the million dollar question, but just curious |
It looks like transmissibility is the key to success. How well you can infect, rather than how pathogenic or nasty the virus is. The hope, as Dr Winston said last week, is we get a variant that causes less disease which pushes out the nastier ones. Not clear is this is the case with Omicron yet. | | | |
| Omicron on 17:28 - Dec 9 with 3179 views | Catullus |
| Omicron on 17:13 - Dec 9 by controversial_jack |
Thank you for the reply, very interesting.Does it mean Variants become weaker or stronger? I know it's the million dollar question, but just curious |
I'm sure the prof has said several times that they hoped new variants would become less troublesome.
It's because a viruses reason for being is to replicate and survive and if it is too deadly and kills too many people it runs out of hosts and so kills itself.
I've seen a fella on TV (a medical expert) saying they always hoped that Covid would mutate into a less harmful version of itself.
It might get more harmful too mind, from what I've read elsewhere. All things are possible. | |
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| Omicron on 17:36 - Dec 9 with 3177 views | Professor |
| Omicron on 17:04 - Dec 8 by A_Fans_Dad |
Here we have the views of a Professor who studied BioChemistry for a short period decades ago on Proteomics.
"Put ivermectin on human ovarian cancer cell line and look at pathways with your fancy proteomics kit. Then claim it identities pathways associated with anti-viral activity. No virus involved"
And
"Biologically it’s complete rubbish"
and
"They have just run pathway analysis following their interrogation. It's complete rubbish. "
and
"Absolutely no way that should have been accepted and is completely the reason it's in a proteomics journal."
"This is just opportunistic crap with no relevance whatsoever."
Then we have the view of the rest of the world view of Proteomics.
"branch of biotechnology concerned with applying the techniques of molecular biology, biochemistry, and genetics to analyzing the structure, function, and interactions of the proteins produced by the genes of a particular cell, tissue, or organism"
"more inclusive definition combines protein studies with analyses that have a genetic readout such as mRNA analysis, genomics, and the yeast two-hybrid analysis (123). However, the goal of proteomics remains the same, i.e., to obtain a more global and integrated view of biology by studying all the proteins of a cell rather than each one individually."
"Proteomics can provide significant biological information for many biological problems, such as:
which proteins interact with a particular protein of interest (for example, the tumour suppressor protein p53)? (Human example)
which proteins are localised to a subcellular compartment (for example, the mitochondrion)? (Human example)
which proteins are involved in a biological process"
"Proteomics is the analysis of complete complements of proteins and includes not only their identification, but also quantitation, determination of cellular location, how they are modified, how they interact with each other, their activities and, ultimately, the elucidation of protein function. This powerful analysis can, for example, allow differences in the protein levels of samples between diseased and normal tissues to be assessed. Proteins are generally enzymatically digested (with or without pre-fractionation) to produce peptides which are then analysed by state-of-the-art mass spectrometry techniques."
"Accordingly, proteomics seeks to do more than just to identify proteins potentially present in a sample, but also to assess protein abundance, localization, posttranslational modifications, isoforms, and molecular interactions. As a discipline, proteomics has grown at the interface of physical and biochemistry, computer science, and bioinformatics, with an emphasis on high throughput and reduced user bias. Accordingly, technologies used are varied, but almost always utilize coupled techniques (i.e., one- or two-dimensional gel electrophoresis/mass spectrometry (MS) or liquid chromatography/MS). "
As the main problem with COVID revolves around the "Spike Proteins" one would think that it was a good technique to use to learn how to inhibit their actions wouldn't you. |
You are monumentally thick aren't you? Either that or you can't actually read properly
The criticism is the biological model. What relationship has putting ivermectin on an ovarian cancer line got to do with how SARS CoV2 behaves in the respiratory tract.
Cut and paste what proteomics is. Lovely. I did not know. Not like I work somewhere that has one of the leading proteomics research centres in the world, to one where there are experts in coronavirus biology using single-cell proteomics to understand the interactions of the virus with host cells. In fact the area was led by a Swansea boy until his retirement last year.
The proteomics bit was Il, it's the rest that is well....
Now read my posts properly before these little rants of google cut and paste.
Once again you do not understand | | | |
| Omicron on 17:38 - Dec 9 with 3176 views | A_Fans_Dad |
An interesting chart on Omicron S1 Spike mutations.
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| Omicron on 18:04 - Dec 9 with 3158 views | felixstowe_jack |
| Omicron on 17:38 - Dec 9 by A_Fans_Dad |
An interesting chart on Omicron S1 Spike mutations.
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Interesting maybe but what does it show. | |
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| Omicron on 18:19 - Dec 9 with 3145 views | A_Fans_Dad |
| Omicron on 18:04 - Dec 9 by felixstowe_jack |
Interesting maybe but what does it show. |
Well, at a guess I would say that it shows that Omicron did not naturally derive from the Delta variant for a start.
In fact that is what the Wuhan Chinese whistleblower says.
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