Saints take on Manchester City at the Etihad Stadium, looking to try and get a result, but perhaps more importantly trying to come through the game with the squad not picking up any more injuries.
Multiple changes for Saints as they take on City with Ralph Hasenhuttl clearly trying to protect his squad ahead of the game against Brighton on Saturday.
Biggest surprise is the return of Alex McCarthy, although Hasenhuttl had hinted at this in the pre match built up, presumably to protect the confidence of Fraser Forster
Starting XI: McCarthy, Bednarek, Vestergaard, Salisu, Bertrand, Stephens, Ward-Prowse, Armstrong, Djenepo, Redmond, Adams.
Subs: Forster, Walker-Peters, Ramsay, Diallo, Watts, Ferry, Minamino, Tella, Nlundulu.
Manchester City
Starting XI: Ederson, Walker, Dias, Laporte, Zinchenko, Fernandinho, Mahrez, Gündogan, De Bruyne, Bernardo, Foden.
Subs: Steffen, Stones, Cancelo, Mendy, Rodri, Torres, Sterling, Jesus, Agüero.